WebMar 5, 2024 · CCL17 is required for induction of intestinal inflammation in mice and has an autocrine effect on dendritic cells that promotes production of inflammatory cytokines … WebFeb 20, 2008 · Introduction Transduction of the granulocyte-macrophage colony stimulating factor (GM-CSF) gene into mouse tumor cells abrogates their tumorigenicity in vivo. Our previous report demonstrated that gene transduction of GM-CSF with either TARC or RANTES chemokines suppressed in vivo tumor formation. In this paper, we examined …
Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine ...
WebSep 1, 2024 · Induction of allergic asthma and treatment Humanized IL-4/IL-4RA mice (4–5 week-old females, n = 7–8) were randomized into four groups: the phosphate-buffered saline (PBS) group (denoted as PBS), the OVA group (denoted as OVA), the OVA + isotype antibody group (denoted as Isotype), and the OVA + positive drug group (denoted as Positive drug). WebFeb 20, 2024 · Inhibiting NFκB or p38 mitogen-activated protein kinase (MAPK) activation did block the TARC production induced by IFNγ/TNFα , indicating that these cytokines use the NFκB/p38 MAPK signaling pathway for TARC induction in keratinocytes. Taken together, this indicates that the regulation of TARC production differs per cell type and most ... evidence informed practice triad
Ccl17 chemokine (C-C motif) ligand 17 [ (house mouse)]
WebThymus and activation-regulated chemokine (TARC) was first identified and cloned from phytohemagglutinin-stimulated peripheral blood mononuclear cells by Imai and … WebAug 21, 2003 · In mice, TARC is expressed in a subset of bone marrow-derived DC and is upregulated after maturation. In vivo, murine TARC is constitutively expressed by thymic DC, lymph node DC and CD11c + cells in the lung [23]. However, TARC expression and the regulation of TARC production in murine LC by Th1/Th2 cytokines have not been … WebJun 6, 1997 · Compared with the high affinity value obtained from binding of TARC-SEAP(His) 6 to CCR4 (K d = 0.5 n m), the potency of TARC in induction of chemotaxis in CCR4-transfected 293/EBNA-1 (EC 50 = 10 n m) or in calcium flux in CCR4-transfected K562 cells (EC 50, 8 n m) appeared to be considerably less. brownwood in the villages fl