WebbThe Polo-like kinase (Plk) family of proteins functions as master regulators of cell-cycle progression, cell division, centrosome maturation, and centriole duplication (1–3). All four members (Plk1–4) of this serine/threonine protein kinase family share sequence similarity and domain structure with the founding
Polo-like kinases: structural variations lead to multiple functions
WebbAmong all PLK family members, PLK1 is the most highly conserved. Plk1 has also been the most extensively studied because of its importance in cell division. The kinase domain of PLK1 phosphorylates Ser or Thr of substrates that contain the consensus motif [D/N/E/Y]-[X]-S/T-[F/Φ; no P]-[Φ/X] [9,23]. Moreover, the kinase domain contains a T- Webb31 juli 2012 · Analysis of the Plk family and development of GPS-Polo. From the scientific literature, we collected 56 experimentally identified Plk phospho-binding sites in 47 proteins (Supplementary Table S1) and 124 Plk substrates with 275 known p-sites (Supplementary Table S2). The statistical results of the data collection are shown in … how to delete other folder in outlook mail
Polo-Like Kinase - an overview ScienceDirect Topics
Webb1 juli 2024 · In the last two decades, the Polo-like kinase (PLK) family has emerged as a key regulator in mitotic regulation, being involved in the complex process from mitotic onset to its termination. The key role in cell proliferation and the frequently observed overexpression in various tumor entities have raised much interest in basic and clinical … Webb10 MIN EXERCISE & STRETCH FOR SHOULDERS, NECK & THE COLLARBONE AREA ~ Emi ,Morning Fitness Routine - Pilates Inspired Stretch, & My Light Ab & Butt Workout... Webb2 juli 2024 · Polo-like kinases (PLKs) are key cell cycle Ser/Thr kinases conserved in metazoan organisms. Four kinase-domain-containing PLK family members are found in most kinomes, and each PLK polypeptide is thought to serve specific functions in cells. Polo-like kinase 4 (PLK4) is the central regulator of centriole assembly [1,2]. how to delete other google accounts