Ligustrazine aromatic acid ether derivatives
Nettet28. feb. 2024 · Ligustrazine-vanillic acid derivatives had been reported to exhibit promising neuroprotective activities. In our continuous effort to develop new ligustrazine derivatives with neuroprotective effects, we attempted the synthesis of several ligustrazine-vanillic acid amide derivatives and screened their protective effect on the … NettetLigustrazine aromatic acid ether derivative of general formula I, its preparation method, pharmaceutical composition and application, wherein Ar is selected from aryl substituted aryl and substituted styryl, R is selected from hydrogen and alkyl with no more than 6 …
Ligustrazine aromatic acid ether derivatives
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Nettet9. des. 2024 · Inspired by these results, twenty-seven additional small molecule heterocyclic dimers linked with decane-1,10-diamine and nine cinnamic acid dimers … Nettet28. feb. 2024 · Meanwhile previous studies showed that many of aromatic acids, such as vanillic acid, protocatechuic acid, salicylic acid, exhibited interesting neuroprotective activity [15–19].In our previous effort to develop new neuroprotective lead compounds, inspired by the potent bioactivities of TMP and aromatic acids on neuroprotection, we …
NettetMicellar conditions are a new direction of study for ether synthesis as they are simple, efficient, economical and environmentally friendly. 1. Introduction Ethers are a class of organic compounds characterized by an oxygen atom bonded to two alkyl or aryl groups (e.g. R–O–R0). Generally ethers may be categorized as aryl ether, allyl ether,
NettetA series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2 … NettetLigustrazine aromatic acid ether derivative of general formula I, its preparation method, pharmaceutical composition and application, wherein Ar is selected from aryl …
Nettet11. apr. 2024 · Antiplatelet aggregation agents have demonstrated clinical benefits in the treatment of ischemic stroke. In our study, a series of novel nitric oxide (NO)-donating ligustrazine derivatives were designed and synthesized as antiplatelet aggregation agents. They were evaluated for the inhibitory effect on 5′-diphosphate (ADP)-induced …
Nettet9. feb. 2024 · A series of ligustrazine-phenolic acid esters which exhibited promising neuroprotective activities have previously been reported. Nevertheless, we found that these ester compounds (like T-VA) were not stable in plasma by further in vivo studies. To investigate plasma-stable neuroprotective agents, a series of new ligustrazine … ordinary members of an organisationNettetfrom publication: Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells A … how to turn off cursing in warzoneNettet27. okt. 2008 · ligustrazine aromatic acid ether derivative, its preparation method, pharmaceutical composition, and application 1 Europe PMC requires Javascript to … how to turn off cyberpower keyboard backlightNettet18. okt. 2013 · Synthesis and protective effect of new ligustrazine-benzoic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells. ... how to turn off cursor hoverNettet27. okt. 2008 · Ligustrazine aromatic acid ether derivative, its preparation method, pharmaceutical composition, and application 1 Europe PMC requires Javascript to … how to turn off cursor modeNettetAccording to different conjunctive positions and numbers of hydroxyls, over 100 novel ligustrazine-phenolic acid derivatives were synthesized and were proved to possess … how to turn off cryo timer arkNettet[origin: EP2213666A1] Ligustrazine aromatic acid ether derivative of general formula I, its preparation method, pharmaceutical composition and application, wherein Ar is … how to turn off cursor pad on laptop