2024 Klf2 macrophage

Klf2 macrophage

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August undefined, 2024

WebOct 28, 2024 · In macrophages of the plaque, KLF2 expression was increased, whereas the MLKL expression was decreased after long-term calycosin administration (Figure 6a). … WebMay 1, 2024 · Klf2 Ldlr Lif Lox Lpl Ltbp2 Mmp2 Mmp3 Mmp9 Msr1 Nfkb1 Npy Pdgfa Pdgfb Pdgfrb Plin2 Ppara Ppard Pparg Sele Sell Selp Selplg Serpinb2 Serpine1 Smad3 Smad4 Spp1 Tgfb1 Tgfb2 Tgfbr1 Timp1 Tnc ... Macrophage scavenger receptor 1 Nuclear factor κ B subunit 1 Neuropeptide Y Platelet-derived growth factor subunit A

Krüppel-like factor 4 regulates macrophage polarization - PMC

Webmacrophages may account for the increase in atherosclerosis. Remarkably, peritoneal macrophages from KLF2 / mice treated with oxidized LDL demonstrated a 40% increase in lipid uptake when compared to wild-type macrophages (Fig-ure 3A and supplemental Figure IIA). Conversely, adenoviral overexpression of KLF2 in a mouse macrophage cell line WebApr 3, 2012 · KLF2 Deficiency Increases Macrophage Adhesion to Endothelial Cells The increase in atherosclerosis observed in myeloid KLF2-deficient hypercholesterolemic mice may be due to elevated macrophage inflammation and/or propensity for lipid accumulation in response to atherogenic lipoprotein stimulation. elearning gym vacha

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WebNov 21, 2024 · Cues from the tissue microenvironment program macrophages for silent AC clearance • KLF2 and KLF4 control expression of genes necessary for silent AC clearance … WebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. The activity of KLF2 is controlled by several … WebOct 10, 2024 · A boxplot of downregulated genes DUSP1, KLF2, PMP22, and ZEB2 was shown. That raised an interesting question about the pathological meaning of downregulated top gene markers. Actually, some markers like ZEB2 exhibited a rather unique expression in macrophages according to the EC1 UMAP plot. food near orem ut

Myeloid-Specific Krüppel-Like Factor 2 Inactivation Increases ...

Activation of GPR30 with G1 inhibits oscillatory shear stress …

WebLoss of KLF2 in macrophages affects the transcription of >1,400 genes, encompassing a wide range of pathways such as metabolism, chemotaxis, and cytokine release (46). This … WebJun 11, 2024 · KLF2 inhibits NF-κB-dependent proinflammatory activation of macrophages ( 56, 57 ). By contrast, KLF6 acts cooperatively with NF-κB to promote proinflammatory … food near otay mesaWebMar 21, 2024 · MEF2 intervened LPS-induced acute lung injury by binding to KLF2 promoter and modulating macrophage phenotype. Renoprotective Effect of KLF2 on Glomerular … food near oracle park

"WebMar 4, 2024 · KLF2 resisted inflammation within macrophages and inhibited M1-type macrophage polarization by recruiting NF-κB cofactors away from the promoters of inflammatory genes . Here, we discovered a novel mechanism involving the inhibition of HSPH1 gene transcription by KLF2 directly binding to its promoter, thus hindering the … " - Klf2 macrophage

Klf2 macrophage

Therapeutic potential of KLF2-induced exosomal microRNAs in

WebApr 1, 2024 · Previous studies have shown that KLF2 is necessary for regulating glycolytic flux. In this study, we overexpressed KLF2 in macrophages to investigate whether KLF2 … WebApr 2, 2009 · Another particularly interesting example of inconsistency is up regulation of KLF2 observed with PMA/U937 cells on the contrary to M-CSF/macrophages that shows down regulation. KLF2 was previously reported to be down regulated upon monocyte differentiation or activation in THP-1 cells, and has been proved to be a negative regulator …

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WebMar 26, 2024 · There are many crucial targets of KLF2, such as eNOS, THBD (thrombomodulin), number of pro-inflammatory, vasoconstrictive and pro-thrombotic genes (PAI1 (plasminogen activator inhibitor-1), SELE... WebApr 11, 2024 · Cd74, the macrophage migration inhibitory factor (MIF) receptor, is enhanced in the KC of systemic sclerosis and may be associated with the proinflammatory pathways [33]. ... Klf2, Klf4, and Klf6 were found to be the key TFs in Col17a1 hi PBC, while Cux1, Dlx3, and Lef1 were the predominant TFs in Cux1 hi PBC.

WebKLF2 can also promote the differentiation and function of B-cell through promoting CD62L, CXCR7, and β7-integrins expression [29]. ... has the function of anti-inflammation and anti-thrombotic through regulating the reaction between endothelial cells and macrophages in the case of atherosclerosis via the Ch25h/LXR axis [6], [34]. WebNov 18, 2024 · KLF2 regulates metaflammation transcription in macrophages RNA-sequencing of bone marrow-derived macrophages (BMDMs) isolated from myeloid …

WebDec 1, 2014 · Macrophages are the building blocks of intimal atherosclerotic lesions where they scavenge and accumulate modified lipoproteins, profoundly affecting lesion development and progression through their roles in lipid metabolism and as major sensors and effectors of the innate immune system. 1 Lesional macrophages originate from … WebFeb 5, 2024 · KLF2 binds directly to the promoter of thombomodulin-1, thereby increasing transcription of this potent anti-thrombotic and anti-inflammatory factor ( 8, 15, 16 ). Additionally, KLF2 inhibits the effects of thrombin-mediated endothelial activation by preventing transcription of thrombin’s receptor, PAR-1 ( 17 ).

WebOct 31, 2024 · KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy Atherosclerosis (AS) is an important cause of common vascular diseases.

WebMar 4, 2024 · KLF2-null mice exhibit abnormal blood vessel formation, resulting in embryonic haemorrhage and death. Within the blood vessel wall, KLF2 is exclusively expressed in endothelial cells and... food near outram parkWebJun 29, 2024 · Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to ... food near osaka castleWebApr 25, 2006 · KLF2 Expression Is Reduced with Monocyte Activation/Differentiation into Macrophages. To better understand the role of KLF2 in the regulation of immune cells … food near oxford valley mallWebDec 28, 2024 · klf2 klf2 expression in endothelium, but not myocardium, prevents this cardiomyocyte extrusion phenotype. Transcriptome analysis of klf2 mutant hearts reveals that Fgf signaling is affected, and accordingly, we find that inhibition of Fgf signaling in wild-type animals can lead to abluminal cardiomyocyte extrusion. elearninggyaschool.com/moodleWebMyeloid KLF2 regulates a macrophage-enriched metabolic network and is responsive to metaflammatory stress a Gene-set enrichment analysis of bone marrow-derived macrophages (BMDMs) from... food near oxford ctWebApr 1, 2024 · CE inhibits glycolysis-mediated M1 macrophage polarization by upregulating KLF2 expression in RAW 264.7 macrophages. (a, b) The expression of KLF2 in RAW 264.7 macrophages treated with siRNA control or si-KLF2 was analyzed by western blotting analysis (n = 3). (c, d) Representative photographs and statistical results of PFKFB3, … food near oxford road manchesterWebApr 30, 2024 · KLF2 is known to be upregulated in response to shear stress and to induce activation of numerous downstream signaling pathways that exert protective effects against atherosclerosis [28, 29]. However, expression of KLF2 is flow-dependent, and OSS had been shown to induce transient upregulation of KLF2 followed by prolonged suppression . To … e learning h0b0