Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. The gene has been discovered in 1990 by in situ hybridisation and it is localised on 17q11.2-q12 chromosome. It is also known as RANTES (regulated on activation, normal T cell expressed and … See more CCL5 belongs to the CC subfamily of chemokines, due to its adjacent cysteines near N terminus. It is an 8kDa protein acting as a classical chemotactic cytokine or chemokine. It consists of 68 amino acids. CCL5 is … See more CCL5 has been shown to interact with CCR3, CCR5 and CCR1. CCL5 also activates the G-protein coupled receptor See more • Chemotaxis • Chemokine See more • Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, et al. (April 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–247. See more CCL5 is involved in transplantations, anti-viral immunity, tumor development and numerous human diseases and disorders, for instance viral hepatitis or COVID-19. For instance, CCL5 level is higher during rejection of renal transplant. Importance of … See more • Human CCL5 genome location and CCL5 gene details page in the UCSC Genome Browser. • Overview of all the structural information available in the PDB for UniProt: P13501 (C-C motif chemokine 5) at the PDBe-KB. See more WebThis chemokine interacts with GPCRs (G-protein-coupled receptors) and GAG (glycosaminoglycan) chains bound to HSPGs (heparan sulfate proteoglycans). Many …
Chemokine RANTES in Severe Pulmonary Arterial Hypertension
WebFeb 16, 2024 · RANTES is an inflammatory chemokine that exhibits chemotaxis towards multiple inflammatory cells, especially T cells via CCR5 [16, 20]. RANTES has been reported to play a role in multiple vascular diseases, tumors, … Web511 Likes, 28 Comments - Dr. Dominik Nischwitz (@drdome1) on Instagram: "What the hell is a CAVITATION ? swipe left “Cavitation” is the laymen’s..." download contacts from icloud to new phone
High-Affinity Binding of Chemokine Analogs that Display Ligand …
WebJul 6, 2024 · Here we report three cryo-electron microscopy structures of G i1 protein-coupled CCR5 in a ligand-free state and in complex with the chemokine MIP-1α or … WebRANTES (Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted) is a chemokine secreted by platelets that have been activated predominantly during flow … WebThis antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Rat RANTES (CCL5) (500-P78Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Rat RANTES (CCL5). Western Blot: To detect Rat RANTES by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. download content amazon kids